diff --git a/src/google/protobuf/port_def.inc b/src/google/protobuf/port_def.inc
index 56f995e45e..bc7a01e534 100644
--- a/src/google/protobuf/port_def.inc
+++ b/src/google/protobuf/port_def.inc
@@ -228,11 +228,12 @@ static_assert(PROTOBUF_ABSL_MIN(20230125, 3),
 #endif
 #if ABSL_HAVE_CPP_ATTRIBUTE(clang::musttail) && !defined(__arm__) &&  \
     !defined(_ARCH_PPC) && !defined(__wasm__) &&                      \
-    !(defined(_MSC_VER) && defined(_M_IX86)) && !defined(__i386__)
+    !(defined(_MSC_VER) && defined(_M_IX86)) && !defined(__i386__) && !defined(__MINGW32__)
 // Compilation fails on ARM32: b/195943306
 // Compilation fails on powerpc64le: b/187985113
 // Compilation fails on X86 Windows:
 // https://github.com/llvm/llvm-project/issues/53271
+// Compilation fails on MINGW: https://github.com/protocolbuffers/protobuf/issues/21625
 #define PROTOBUF_MUSTTAIL [[clang::musttail]]
 #define PROTOBUF_TAILCALL true
 #else